AT-130
Names
[ CAS No. ]:
211364-06-6
[ Name ]:
AT-130
Biological Activity
[Description]:
AT-130 is a potent inhibitor of HBV capsid assembly, inhibits wild-type HBV replication with IC50 of 2.4 uM; inhibits replication of wild-type and lamivudine-resistant strains of hepatitis B virus in vitro with same sensitivity (rtL180M, rtM204I, and rtL180M + rtM204V); blocks HBV replication at the level of viral RNA packaging, interferes with capsid morphogenesis, shows activity against the main lamivudine- and adefovir-resistant mutants.
[References]
References 1. Delaney WE 4th, et al. Antimicrob Agents Chemother. 2002 Sep;46(9):3057-60. 2. Feld JJ, et al. Antiviral Res. 2007 Nov;76(2):168-77. 3. Billioud G, et al. Antiviral Res. 2011 Nov;92(2):271-6. View Related Products by Target HBV
Chemical & Physical Properties
[ Molecular Formula ]:
C22H22BrN3O5
[ Molecular Weight ]:
488.338
Safety Information
[ Hazard Codes ]:
Xi