2099681-31-7

2099681-31-7 structure

2099681-31-7 structure

Name: AT-121
Chemical Name: AT-121
CAS Number: 2099681-31-7
Molecular Formula: C₂₄H₃₈N₄O₃S
Molecular Weight: 462.65
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2020-08-08 12:59:21
Modify Date: 2024-01-09 17:29:13
AT-121 is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects[1].

Name	AT-121

Description	AT-121 is a bifunctional nociception and mu opioid receptor agonist, with Kis of 3.67 and 16.49 nM, respectively. AT-121 is a safe, non-addictive analgesic, and shows antinociceptive and antiallodynic effects[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
In Vivo	AT-121 (0.003-0.03 mg/kg; s.c.) produces potent antinociceptive effect[1]. Animal Model: Adult male and female rhesus monkeys[1] Dosage: 0.003-0.03 mg/kg Administration: Subcutaneous Result: Produced antinociceptive effects against an acute noxious stimulus, 50 °C water, in a dose-dependent.
References	[1]. Ding H, Kiguchi N, Yasuda D, et al. A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates. Sci Transl Med. 2018;10(456):eaar3483. doi:10.1126/scitranslmed.aar3483

Molecular Formula	C₂₄H₃₈N₄O₃S
Molecular Weight	462.65