JC-171
Modify Date: 2025-08-30 10:34:23
JC-171 structure
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Common Name | JC-171 | ||
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| CAS Number | 2112809-98-8 | Molecular Weight | 384.831 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H17ClN2O5S | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of JC-171JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM; interferes with NLRP3/ASC interaction induced by LPS/ATP stimulation both in vtiro and in vivo; delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE). |
| Name | JC-171 |
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| Description | JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM; interferes with NLRP3/ASC interaction induced by LPS/ATP stimulation both in vtiro and in vivo; delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE). |
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| References | References 1. Guo C, et al. ACS Chem Neurosci. 2017 Jul 13. doi: 10.1021/acschemneuro.7b00124. View Related Products by Target NOD-like Receptor (NLR) |
| Molecular Formula | C16H17ClN2O5S |
|---|---|
| Molecular Weight | 384.831 |
| InChIKey | KQRQPMUPYDOTCA-UHFFFAOYSA-N |
| SMILES | COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NO)cc1 |
| Hazard Codes | Xi |
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