2112809-98-8
2112809-98-8 structure
- Name: JC-171
- Chemical Name: JC-171
- CAS Number: 2112809-98-8
- Molecular Formula: C16H17ClN2O5S
- Molecular Weight: 384.831
- Catalog: Signaling Pathways Immunology/Inflammation NOD-like Receptor (NLR)
- Create Date: 2020-01-12 13:12:49
- Modify Date: 2023-01-18 11:14:38
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JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM; interferes with NLRP3/ASC interaction induced by LPS/ATP stimulation both in vtiro and in vivo; delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE).
| Name | JC-171 |
|---|
| Description | JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM; interferes with NLRP3/ASC interaction induced by LPS/ATP stimulation both in vtiro and in vivo; delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE). |
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| References | References 1. Guo C, et al. ACS Chem Neurosci. 2017 Jul 13. doi: 10.1021/acschemneuro.7b00124. View Related Products by Target NOD-like Receptor (NLR) |
| Molecular Formula | C16H17ClN2O5S |
|---|---|
| Molecular Weight | 384.831 |
| Hazard Codes | Xi |
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