JC-171

Names

[ Name ]:
JC-171

Biological Activity

[Description]:

JC-171 is a selective NLRP3 inflammasome inhibitor that inhibits LPS/ATP-induced IL-1β release from macrophages with IC50 of 8.45 uM; interferes with NLRP3/ASC interaction induced by LPS/ATP stimulation both in vtiro and in vivo; delays the progression and reduces the severity of experimental autoimmune encephalomyelitis (EAE).

[References]

References 1. Guo C, et al. ACS Chem Neurosci. 2017 Jul 13. doi: 10.1021/acschemneuro.7b00124. View Related Products by Target NOD-like Receptor (NLR)

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₁₇ClN₂O₅S

[ Molecular Weight ]:
384.831

Safety Information

[ Hazard Codes ]:
Xi

Related Compounds

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