OP-3633

Modify Date: 2024-01-09 19:51:34

OP-3633 structure	Common Name	OP-3633
	CAS Number	2102494-14-2	Molecular Weight	445.64
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₀H₃₉NO₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of OP-3633

OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1].

Name	OP-3633

Description	OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1].
Related Catalog	Research Areas >> Inflammation/Immunology Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
Target	IC50: 29 nM (GR)[1]
In Vitro	OP-3633 exhibits low progesterone receptor (PR) agonism with an EC50 higher than 2500 nM[1]. OP-3633 exhibits low androgen receptor (PR) antagonism, with an IC50 of 1135 nM[1].
References	[1]. Du X, et al. Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633). J Med Chem. 2019 Jul 25;62(14):6751-6764.

Molecular Formula	C₃₀H₃₉NO₂
Molecular Weight	445.64

OP-3633

Use of OP-3633

Names

OP-3633 Biological Activity

Chemical & Physical Properties