OP-3633

Modify Date: 2025-08-25 11:45:22

OP-3633 Structure
OP-3633 structure
 Common Name OP-3633
CAS Number 2102494-14-2 Molecular Weight 445.64
Density N/A Boiling Point N/A
Molecular Formula C30H39NO2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of OP-3633


OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1].

 Names

Name OP-3633

 OP-3633 Biological Activity

Description OP-3633 is a potent and selective steroidal glucocorticoid receptor (GR) antagonist with an IC50 of 29 nM, with inhibition of GR transcriptional activity. OP-3633 exhibits low progesterone receptor (PR) agonism and androgen receptor (AR) antagonism[1].
Related Catalog
Target

IC50: 29 nM (GR)[1]

In Vitro OP-3633 exhibits low progesterone receptor (PR) agonism with an EC50 higher than 2500 nM[1]. OP-3633 exhibits low androgen receptor (PR) antagonism, with an IC50 of 1135 nM[1].
References

[1]. Du X, et al. Discovery of a Potent Steroidal Glucocorticoid Receptor Antagonist with Enhanced Selectivity against the Progesterone and Androgen Receptors (OP-3633). J Med Chem. 2019 Jul 25;62(14):6751-6764.

 Chemical & Physical Properties

Molecular Formula C30H39NO2
Molecular Weight 445.64
InChIKey LJUSMSPTDKGAFT-LMNHVJTASA-N
SMILES CC#CC1(O)CCC2C3CCC4=CC(=O)CCC4(C)C3C(c3ccc(N(C)C)cc3)CC21C
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Chemsrc provides OP-3633(CAS#:2102494-14-2) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of OP-3633 are included as well.>> amp version: OP-3633

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