1443752-76-8
1443752-76-8 structure
- Name: OP-1074
- Chemical Name: OP-1074
- CAS Number: 1443752-76-8
- Molecular Formula: C29H31NO4
- Molecular Weight: 457.56
- Catalog: Research Areas Cancer
- Create Date: 2020-01-24 07:58:51
- Modify Date: 2024-01-10 10:57:07
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OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD), shows specific antiestrogenic activity for ERα and ERβ, inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC50 of 1.6 and 3.2 nM, respectively[1].
| Name | OP-1074 |
|---|
| Description | OP-1074 is a pure antiestrogen and a selective ER degrader (PA-SERD), shows specific antiestrogenic activity for ERα and ERβ, inhibits 17β-estradiol (E2)-stimulated transcriptional activity with IC50 of 1.6 and 3.2 nM, respectively[1]. |
|---|---|
| Related Catalog | |
| Target |
ERα ERβ |
| In Vitro | OP-1074 (0-100 nM; 24 hours) inhibits MCF-7 cells and CAMA-1 cells proliferation with IC50 values of 6.3 and 9.2 nM, respectively[1]. OP-1074 (100 nM; 24 hours) destabilizatizes ERα protein expression in MCF-7 and CAMA-1 cells[1]. Cell Viability Assay[1] Cell Line: MCF-7 cells, CAMA-1 cells Concentration: 0 nM, 10 nM,100 nM Incubation Time: 24 hours Result: Inhibited breast cancer cell proliferation. Western Blot Analysis[1] Cell Line: MCF-7 cells, CAMA-1 cells Concentration: 100 nM Incubation Time: 24 hours Result: Downregulated ERα protein expression. |
| References |
| Molecular Formula | C29H31NO4 |
|---|---|
| Molecular Weight | 457.56 |