L-Cysteinesulfinic acid monohydrate

Modify Date: 2024-01-13 11:10:56

L-Cysteinesulfinic acid monohydrate structure	Common Name	L-Cysteinesulfinic acid monohydrate
	CAS Number	207121-48-0	Molecular Weight	171.17200
	Density	N/A	Boiling Point	580.6ºC at 760 mmHg
	Molecular Formula	C₃H₉NO₅S	Melting Point	163ºC (dec.)(lit.)
	MSDS	Chinese USA	Flash Point	304.9ºC
	Symbol	GHS07	Signal Word	Warning

Use of L-Cysteinesulfinic acid monohydrate

L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].

Name	L-Cysteinesulfinic Acid, Monohydrate
Synonym	More Synonyms

Description	L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
Target	mGluR1:3.92 (pEC50) mGluR2:3.9 (pEC50) mGluR4:2.7 (pEC50) mGluR5:4.6 (pEC50) mGluR6:4.0 (pEC50) mGluR8:3.94 (pEC50)
In Vitro	L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing[1].
References	[1]. Shi Q, et al. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther. 2003 Apr;305(1):131-42. [2]. Boss V, et al. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity.

Boiling Point	580.6ºC at 760 mmHg
Melting Point	163ºC (dec.)(lit.)
Molecular Formula	C₃H₉NO₅S
Molecular Weight	171.17200
Flash Point	304.9ºC
Exact Mass	171.02000
PSA	129.06000
LogP	0.12170
Vapour Pressure	2.73E-15mmHg at 25°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi
Risk Phrases	36/37/38
Safety Phrases	26-36
RIDADR	NONH for all modes of transport
HS Code	2930909090