1115-65-7
1115-65-7 structure
- Name: L-Cysteinesulfinic acid
- Chemical Name: 3-sulfino-L-alanine
- CAS Number: 1115-65-7
- Molecular Formula: C3H7NO4S
- Molecular Weight: 153.16
- Catalog: Signaling Pathways GPCR/G Protein mGluR
- Create Date: 2018-08-16 16:43:44
- Modify Date: 2025-08-20 18:10:35
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L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92±0.03, 4.6±0.2, 3.9±0.2, 2.7±0.2, 4.0±0.2, and 3.94±0.08 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively.
| Name | 3-sulfino-L-alanine |
|---|---|
| Synonyms |
L-cysteine sulfinic acid
2-amino-3-sulfino-propanoic acid L-cysteine sulphinic acid EINECS 214-228-5 3-sulphino-L-alanine cysteinsulphinic acid 3-Sulfinoalanine L-CYSTEINESULFINIC ACID 1-HYDRATE m-Chlorophenylbiguanide hydrochloride 2-amino-3-sulfino-propionic acid Cysteine sulphinic acid L-Cysteinesulfinic acid MFCD00044889 |
| Description | L-Cysteinesulfinic acid is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92±0.03, 4.6±0.2, 3.9±0.2, 2.7±0.2, 4.0±0.2, and 3.94±0.08 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively. |
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| Related Catalog | |
| Target |
Human Endogenous Metabolite |
| In Vitro | L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increasesin cell firing[1]. |
| References |
| Density | 1.828g/cm3 |
|---|---|
| Boiling Point | 492.8ºC at 760mmHg |
| Melting Point | >130°C (dec.) (lit.) |
| Molecular Formula | C3H7NO4S |
| Molecular Weight | 153.16 |
| Flash Point | 251.8ºC |
| Exact Mass | 153.01000 |
| PSA | 119.83000 |
| LogP | 0.18600 |
| Vapour Pressure | 4.68E-11mmHg at 25°C |
| Index of Refraction | 1.673 |
| Hazard Codes | Xi: Irritant; |
|---|---|
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| HS Code | 2930909090 |
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| Literature: Hope,D.P. et al. Journal of the Chemical Society [Section] C: Organic, 1970 , p. 270 - 273 |
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| Literature: Perez-Benito, Joaquin F.; Arias, Conchita Journal of Physical Chemistry A, 1998 , vol. 102, # 29 p. 5837 - 5845 |
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| Literature: Mishra, Ritu; Mukhopadhyay, Subrata; Banerjee, Rupendranath Dalton Transactions, 2010 , vol. 39, # 10 p. 2692 - 2696 |
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Detail
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| Literature: Gottardi, Waldemar; Nagl, Markus Archiv der Pharmazie, 2002 , vol. 335, # 9 p. 411 - 421 |
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |