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207121-48-0

207121-48-0 structure
207121-48-0 structure
  • Name: L-Cysteinesulfinic acid monohydrate
  • Chemical Name: L-Cysteinesulfinic Acid, Monohydrate
  • CAS Number: 207121-48-0
  • Molecular Formula: C3H9NO5S
  • Molecular Weight: 171.17200
  • Catalog: Signaling Pathways GPCR/G Protein mGluR
  • Create Date: 2018-04-01 08:00:00
  • Modify Date: 2025-08-25 18:19:21
  • L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].
Name L-Cysteinesulfinic Acid, Monohydrate
Synonyms MFCD00150732
EINECS 214-228-5
L-cysteinesulfinic acid monohydrate
Description L-Cysteinesulfinic acid monohydrate is a potent agonist at several rat metabotropic glutamate receptors (mGluRs) with pEC50s of 3.92, 4.6, 3.9, 2.7, 4.0, and 3.94 for mGluR1, mGluR5, mGluR2, mGluR4, mGluR6, and mGluR8, respectively[1].
Related Catalog
Target

mGluR1:3.92 (pEC50)

mGluR2:3.9 (pEC50)

mGluR4:2.7 (pEC50)

mGluR5:4.6 (pEC50)

mGluR6:4.0 (pEC50)

mGluR8:3.94 (pEC50)

In Vitro L-Cysteinesulfinic acid is an endogenous agonist of a metabotropic receptor coupled to stimulation of phospholipase D (PLD) activity. L-CSA is an endogenous agonist of the PLD-coupled metabotropic excitatory amino acids (EAA) receptor. L-CSA selectively activates the PLD-coupled receptor. 1 mM L-CSA induces a significant increase in PLD activity in hippocampal slices, whereas 1 mM concentrations of L-glutamate, L-aspartate, and L-HCA are without effect. L-CSA elicits a dose-dependent increase in PLD activity in rat hippocampal slices in the presence of iGluR antagonists, with an approximate EC50 of 500 uM. The PLD response induced by 1 mM L-CSA is not significantly decreased in the presence of 1 uM tetrodotoxin, suggesting that this response is not dependent upon L-CSA-induced increases in cell firing[1].
References

[1]. Shi Q, et al. L-homocysteine sulfinic acid and other acidic homocysteine derivatives are potent and selective metabotropic glutamate receptor agonists. J Pharmacol Exp Ther. 2003 Apr;305(1):131-42.

[2]. Boss V, et al. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity.
Boiling Point 580.6ºC at 760 mmHg
Melting Point 163ºC (dec.)(lit.)
Molecular Formula C3H9NO5S
Molecular Weight 171.17200
Flash Point 304.9ºC
Exact Mass 171.02000
PSA 129.06000
LogP 0.12170
Vapour Pressure 2.73E-15mmHg at 25°C
Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36
RIDADR NONH for all modes of transport
HS Code 2930909090
HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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