Calycosin
Modify Date: 2024-01-03 16:18:43
Calycosin structure
|
Common Name | Calycosin | ||
|---|---|---|---|---|
| CAS Number | 20575-57-9 | Molecular Weight | 284.263 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 536.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C16H12O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 205.7±23.6 °C | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of CalycosinCalycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity.IC50 value:Target: in vitro: calycosin had obvious anti-proliferation effects on SKOV3 cells in a dose- and time-dependent manner. calycosin up-regulated the Bax/Bcl-2 ratio and cleaved caspase-3, cleaved caspase-9 expression in a dose-dependent manner. In summary, calycosin might exert anti-growth and induce-apoptosis activity against ovarian cancer SKOV3 cells through activating caspases and Bcl-2 family proteins, therefore presenting as a promising therapeutic agent for the treatment of ovarian cancer [1]. Both calycosin and genistein inhibited proliferation and induced apoptosis in MCF-7 breast cancer cells, especially after treatment with calycosin. Treatment of MCF-7 cells with calycosin or genistein resulted in decreased phosphorylation of Akt, and decreased expression of its downstream target, HOTAIR [2]. incubation of calycosin resulted in enhanced expression ERβ in MCF-7 and T-47D cells, rather than MDA-231 and MDA-435 cells. Moreover, with the upregulation of ERβ, successive changes in downstream signaling pathways were found, including inactivation of insulin-like growth factor 1 receptor (IGF-1R), then stimulation of p38 MAPK and suppression of the serine/threonine kinase (Akt), and finally poly(ADP-ribose) polymerase 1 (PARP-1) cleavage [3].in vivo: calycosin stimulated a dramatic increase in uterine weight and downregulated the level of ERα protein in OVX mice [4]. |
| Name | calycosin |
|---|---|
| Synonym | More Synonyms |
| Description | Calycosin (Cyclosin) is a natural active compound with anti-oxidative and anti-inflammation activity.IC50 value:Target: in vitro: calycosin had obvious anti-proliferation effects on SKOV3 cells in a dose- and time-dependent manner. calycosin up-regulated the Bax/Bcl-2 ratio and cleaved caspase-3, cleaved caspase-9 expression in a dose-dependent manner. In summary, calycosin might exert anti-growth and induce-apoptosis activity against ovarian cancer SKOV3 cells through activating caspases and Bcl-2 family proteins, therefore presenting as a promising therapeutic agent for the treatment of ovarian cancer [1]. Both calycosin and genistein inhibited proliferation and induced apoptosis in MCF-7 breast cancer cells, especially after treatment with calycosin. Treatment of MCF-7 cells with calycosin or genistein resulted in decreased phosphorylation of Akt, and decreased expression of its downstream target, HOTAIR [2]. incubation of calycosin resulted in enhanced expression ERβ in MCF-7 and T-47D cells, rather than MDA-231 and MDA-435 cells. Moreover, with the upregulation of ERβ, successive changes in downstream signaling pathways were found, including inactivation of insulin-like growth factor 1 receptor (IGF-1R), then stimulation of p38 MAPK and suppression of the serine/threonine kinase (Akt), and finally poly(ADP-ribose) polymerase 1 (PARP-1) cleavage [3].in vivo: calycosin stimulated a dramatic increase in uterine weight and downregulated the level of ERα protein in OVX mice [4]. |
|---|---|
| Related Catalog | |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 536.8±50.0 °C at 760 mmHg |
| Molecular Formula | C16H12O5 |
| Molecular Weight | 284.263 |
| Flash Point | 205.7±23.6 °C |
| Exact Mass | 284.068481 |
| PSA | 79.90000 |
| LogP | 2.41 |
| Appearance of Characters | white to light yellow |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.669 |
| Storage condition | 2-8°C |
| Water Solubility | methanol: soluble1mg/mL, clear, colorless |
|
~62%
Calycosin CAS#:20575-57-9 |
| Literature: Bhandari, Prabha; Crombie, Leslie; Daniels, Peter; Holden, Ian; Bruggen, Nicholas Van; Whiting, Donald A. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 7 p. 839 - 850 |
|
~%
Calycosin CAS#:20575-57-9
Detail
|
| Literature: Journal of Agricultural and Food Chemistry, , vol. 52, # 21 p. 6623 - 6632 |
| HS Code | 2914509090 |
|---|---|
| Summary | HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
|
Thermal stability of kudzu root (Pueraria Radix) isoflavones as additives to beef patties.
J. Food Sci. Technol. 52(3) , 1578-85, (2015) Kudzu root, Pueraria radix, extracts are a rich source of isoflavones. This study investigates the thermal stability of Pueraria radix extracts as a natural nutraceutical supplement in beef patties. T... |
|
|
Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of Astragali Radix and Angelica Sinensis Radix: An evaluation by using calycosin-knock out herbal extract.
J. Ethnopharmacol. 168 , 150-7, (2015) Danggui Buxue Tang (DBT) is a classical Chinese herbal decoction containing two herbs, Astragali Radix (AR) and Angelicae Sinensis Radix (ASR), which serves as dietary supplement for treating women me... |
|
|
Protective effects of calycosin against CCl4-induced liver injury with activation of FXR and STAT3 in mice.
Pharm. Res. 32(2) , 538-48, (2015) Investigating the hepatoprotective effect of calycosin against acute liver injury in association with FXR activation and STAT3 phosphorylation.The acute liver injury model was established by intraperi... |
| 7,5'-dihydroxy-4'-methoxyisoflavone |
| 4H-1-Benzopyran-4-one, 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)- |
| 7,3'-dihydroxy-4'-methoxyisoflavone |
| 7-Hydroxy-3-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one |
| 7-hydroxy-3-(3-hydroxy-4-methoxyphenyl)chromen-4-one |
| 3'-hydroxyformononetin |
| 3',7-Dihydroxy-4'-methoxy-isoflavone |
| Calycosin |
| 3',7-dihydroxy-4'-methoxyisoflavone |
| 7,3'-dihydroxy-4'-methoxyisoflavanon-2-ene |
- BioBioPha
- China
- Product Name: Calycosin
- Price: ￥Inquiry/20mg
- Purity: 98.0%
- Stocking Period: 1 Day
- Contact: Xueping-Zheng
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Calycosin
- Price: ￥788.0/20mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: Calycosin
- Price: $400.0/50mg $600.0/100mg $950.0/250mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Calycosin
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
Get all suppliers and price by the below link:
Price: $264/10mM*1mLinDMSO
Reference only. check more Calycosin price