GNE 5729
Modify Date: 2025-08-23 20:16:06
GNE 5729 structure
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Common Name | GNE 5729 | ||
|---|---|---|---|---|
| CAS Number | 2026635-66-3 | Molecular Weight | 428.195 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 527.6±60.0 °C at 760 mmHg | |
| Molecular Formula | C17H10Cl2F3N5O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 272.9±32.9 °C | |
Use of GNE 5729GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. |
| Name | GNE 5729 |
|---|---|
| Synonym | More Synonyms |
| Description | GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively. |
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| Related Catalog | |
| Target |
EC50: 37 nM (GluN2A), 4.7 μM (GluN2C), 9.5 μM (GluN2D)[1] |
| In Vitro | GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively[1]. |
| References |
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 527.6±60.0 °C at 760 mmHg |
| Molecular Formula | C17H10Cl2F3N5O |
| Molecular Weight | 428.195 |
| Flash Point | 272.9±32.9 °C |
| Exact Mass | 427.021454 |
| LogP | 2.73 |
| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
| Index of Refraction | 1.702 |
| MFCD30829916 |
| (1R,2R)-2-(7-Chloro-2-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropanecarbonitrile |
| Cyclopropanecarbonitrile, 2-[7-chloro-2-[[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl]-, (1R,2R)- |