GNE 5729

Modify Date: 2024-01-12 16:08:43

GNE 5729 structure	Common Name	GNE 5729
	CAS Number	2026635-66-3	Molecular Weight	428.195
	Density	1.7±0.1 g/cm3	Boiling Point	527.6±60.0 °C at 760 mmHg
	Molecular Formula	C₁₇H₁₀Cl₂F₃N₅O	Melting Point	N/A
	MSDS	N/A	Flash Point	272.9±32.9 °C

Use of GNE 5729

GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.

Name	GNE 5729
Synonym	More Synonyms

Description	GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively.
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease
Target	EC50: 37 nM (GluN2A), 4.7 μM (GluN2C), 9.5 μM (GluN2D)[1]
In Vitro	GNE 5729 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 37 nM for GluN2A, 4.7 and 9.5 μM for GluN2C and GluN2D, respectively[1].
References	[1]. Villemure E, et al. GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved in Vivo Profile. ACS Med Chem Lett. 2016 Oct 31;8(1):84-89.

Density	1.7±0.1 g/cm3
Boiling Point	527.6±60.0 °C at 760 mmHg
Molecular Formula	C₁₇H₁₀Cl₂F₃N₅O
Molecular Weight	428.195
Flash Point	272.9±32.9 °C
Exact Mass	427.021454
LogP	2.73
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.702

MFCD30829916

(1R,2R)-2-(7-Chloro-2-{[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl}-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl)cyclopropanecarbonitrile

Cyclopropanecarbonitrile, 2-[7-chloro-2-[[5-chloro-3-(trifluoromethyl)-1H-pyrazol-1-yl]methyl]-4-oxo-4H-pyrido[1,2-a]pyrimidin-6-yl]-, (1R,2R)-

GNE 5729

Use of GNE 5729

Names

GNE 5729 Biological Activity

Chemical & Physical Properties

Synonyms