2315311-83-0

2315311-83-0 structure

2315311-83-0 structure

Name: GNE-9278
Chemical Name: GNE-9278
CAS Number: 2315311-83-0
Molecular Formula: C₂₁H₂₇N₅O₃S
Molecular Weight: 429.54
Catalog: Signaling Pathways Membrane Transporter/Ion Channel iGluR
Create Date: 2020-08-09 16:56:25
Modify Date: 2024-01-10 10:44:55
GNE-9278 is a highly selective positive allosteric modulator of NMDAR that acts at the GluN1 transmembrane domain (TMD). GNE-9278 acts on activated NMDARs to increase peak current and agonist affinity[1].

Name	GNE-9278

Description	GNE-9278 is a highly selective positive allosteric modulator of NMDAR that acts at the GluN1 transmembrane domain (TMD). GNE-9278 acts on activated NMDARs to increase peak current and agonist affinity[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
Target	NMDAR[1]
In Vitro	GNE-9278 (50 μM) slows deactivation with multiple agonists (D-Glu, L-Glu and L-CCG-IV) and enhances the potency of both Glu and Gly[1]. GNE-9278 robustly potentiates GluN2A, 2B, 2C and 2D-containing NMDARs as measured by calcium influx assays from HEK cell lines with the EC50s of 0.74, 3.07, 0.47, and 0.32 μM, respectively[1].
References	[1]. Wang TM, et, al. A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology. . 2017 Jul 15; 121: 204-218.

Molecular Formula	C₂₁H₂₇N₅O₃S
Molecular Weight	429.54