4-PPBP maleate

Modify Date: 2025-08-27 11:39:56

4-PPBP maleate structure	Common Name	4-PPBP maleate
	CAS Number	201216-39-9	Molecular Weight	409.518
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₅H₃₁NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of 4-PPBP maleate

4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3].

Name	4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1)
Synonym	More Synonyms

Description	4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> Sigma Receptor Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	4-PPBP maleate elicits ERK1/2 phosphorylation in primary neurons[3].
In Vivo	4-PPBP maleate (1 μmol/kg; i.v.) decreases brain injury after transient focal ischemia in rats[2]. Animal Model: Male rats weighing 300 to 385 g (Transient focal ischemia model)[2] Dosage: 1 μmol/kg Administration: Per hour by continuous intravenous infusion starting 1 hour after the initiation of ischemia and continuing through 22 hours of reperfusion. Result: Decreased brain injury after transient focal ischemia in rats.
References	[1]. Whittemore ER, et al. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition. J Pharmacol Exp Ther. 1997;282(1):326-338. [2]. Takahashi H, et al. PPBP [4-phenyl-1-(4-phenylbutyl) piperidine] decreases brain injury after transient focal ischemia in rats. Stroke. 1996;27(11):2120-2123. [3]. Tan F, et al. The σ 1 receptor agonist 4-PPBP elicits ERK1/2 phosphorylation in primary neurons: a possible mechanism of neuroprotective action. Neuropharmacology. 2010;59(6):416-424.

Molecular Formula	C₂₅H₃₁NO₄
Molecular Weight	409.518
Exact Mass	409.225311

4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-but-2-enedioate (1:1)

4-Phenyl-1-(4-phenylbutyl)piperidine (2Z)-2-butenedioate (1:1)

Piperidine, 4-phenyl-1-(4-phenylbutyl)-, (2Z)-2-butenedioate (1:1)

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4-PPBP maleate

Use of 4-PPBP maleate

Names

4-PPBP maleate Biological Activity

Chemical & Physical Properties

Synonyms

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.