VPC-14228

Modify Date: 2025-08-25 12:53:02

VPC-14228 Structure
VPC-14228 structure
Common Name VPC-14228
CAS Number 19983-28-9 Molecular Weight 246.32800
Density N/A Boiling Point N/A
Molecular Formula C13H14N2OS Melting Point N/A
MSDS Chinese USA Flash Point N/A
Symbol GHS07
GHS07
Signal Word Warning

 Use of VPC-14228


VPC-14228 is a potent androgen receptor DNA binding domain (AR-DBD) inhibitor that interferes with the interaction of AR with androgen response elements and effectively blocks AR transcriptional activity. VPC-14228 can be used in prostate cancer research[1].

 Names

Name 4-(4-phenyl-1,3-thiazol-2-yl)morpholine
Synonym More Synonyms

 VPC-14228 Biological Activity

Description VPC-14228 is a potent androgen receptor DNA binding domain (AR-DBD) inhibitor that interferes with the interaction of AR with androgen response elements and effectively blocks AR transcriptional activity. VPC-14228 can be used in prostate cancer research[1].
Related Catalog
References

[1]. Kush Dalal, et al. Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer. J Biol Chem. 2014 Sep 19;289(38):26417-26429.  

 Chemical & Physical Properties

Molecular Formula C13H14N2OS
Molecular Weight 246.32800
Exact Mass 246.08300
PSA 53.60000
LogP 2.71170

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302-H319
Precautionary Statements P301 + P312 + P330-P305 + P351 + P338
RIDADR NONH for all modes of transport

 Synthetic Route

~68%

VPC-14228 Structure

VPC-14228

CAS#:19983-28-9

Literature: Keil, D.; Hartmann, H. Liebigs Annalen, 1995 , # 6 p. 979 - 984

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VPC-14228 Structure

VPC-14228

CAS#:19983-28-9

Literature: Teller, J.; Dehne, H.; Zimmermann, T.; Fischer, G. W.; Olk, B. Journal fuer Praktische Chemie (Leipzig), 1990 , vol. 332, # 4 p. 453 - 460

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VPC-14228 Structure

VPC-14228

CAS#:19983-28-9

Literature: Ohtsuka; Toyofuku; Miyasaka; Arakawa Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 12 p. 3234 - 3242

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VPC-14228 Structure

VPC-14228

CAS#:19983-28-9

Literature: Perova, N. M.; Egorova, L. G.; Sidorova, L. P.; Novikova, A. P.; Chupakhin, O. N. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1993 , vol. 29, # 4 p. 487 Khimiya Geterotsiklicheskikh Soedinenii, 1993 , # 4 p. 565 - 566

 Synonyms

2-morpholino-5-phenylthiazole
2-Morpholinyl-4-phenylthiazol
2-Morpholino-4-phenylthiazol
2-morpholino-4-phenyl-thiazole
4-Phenyl-2-morpholinyl-thiazol
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