DC Chemicals Limited
China
Product Name: VPC-14228
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao
Email: sales@dcchemicals.com

19983-28-9

19983-28-9 structure

Name: VPC-14228
Chemical Name: 4-(4-phenyl-1,3-thiazol-2-yl)morpholine
CAS Number: 19983-28-9
Molecular Formula: C₁₃H₁₄N₂OS
Molecular Weight: 246.32800
Catalog: Research Areas Cancer
Create Date: 2017-09-05 07:29:09
Modify Date: 2025-08-25 12:53:02
VPC-14228 is a potent androgen receptor DNA binding domain (AR-DBD) inhibitor that interferes with the interaction of AR with androgen response elements and effectively blocks AR transcriptional activity. VPC-14228 can be used in prostate cancer research[1].

Name	4-(4-phenyl-1,3-thiazol-2-yl)morpholine
Synonyms	2-morpholino-5-phenylthiazole 2-Morpholinyl-4-phenylthiazol 2-Morpholino-4-phenylthiazol 2-morpholino-4-phenyl-thiazole 4-Phenyl-2-morpholinyl-thiazol

Description	VPC-14228 is a potent androgen receptor DNA binding domain (AR-DBD) inhibitor that interferes with the interaction of AR with androgen response elements and effectively blocks AR transcriptional activity. VPC-14228 can be used in prostate cancer research[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Androgen Receptor
References	[1]. Kush Dalal, et al. Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer. J Biol Chem. 2014 Sep 19;289(38):26417-26429.

Molecular Formula	C₁₃H₁₄N₂OS
Molecular Weight	246.32800
Exact Mass	246.08300
PSA	53.60000
LogP	2.71170

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H319
Precautionary Statements	P301 + P312 + P330-P305 + P351 + P338
RIDADR	NONH for all modes of transport

14294-10-1

70-11-1

~68%

19983-28-9

Literature: Keil, D.; Hartmann, H. Liebigs Annalen, 1995 , # 6 p. 979 - 984

110-91-8

5399-30-4

19983-28-9

Literature: Teller, J.; Dehne, H.; Zimmermann, T.; Fischer, G. W.; Olk, B. Journal fuer Praktische Chemie (Leipzig), 1990 , vol. 332, # 4 p. 453 - 460

110-91-8

6094-68-4

19983-28-9

Literature: Ohtsuka; Toyofuku; Miyasaka; Arakawa Chemical and Pharmaceutical Bulletin, 1975 , vol. 23, # 12 p. 3234 - 3242

64581-23-3

19983-28-9

Literature: Perova, N. M.; Egorova, L. G.; Sidorova, L. P.; Novikova, A. P.; Chupakhin, O. N. Chemistry of Heterocyclic Compounds (New York, NY, United States), 1993 , vol. 29, # 4 p. 487 Khimiya Geterotsiklicheskikh Soedinenii, 1993 , # 4 p. 565 - 566

Precursor 6
14294-10-1 70-11-1 110-91-8 5399-30-4
6094-68-4 64581-23-3
DownStream 0

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