ROCK2-IN-2

Modify Date: 2024-01-13 22:38:42

ROCK2-IN-2 structure	Common Name	ROCK2-IN-2
	CAS Number	1995065-79-6	Molecular Weight	360.39
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₁₂N₆OS	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of ROCK2-IN-2

ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM.

Name	ROCK2-IN-2

Description	ROCK2-IN-2 is a selective ROCK2 inhibitor extracted from patent US20180093978A1, Compound A-30, has an IC50 of <1 μM.
Related Catalog	Signaling Pathways >> Cell Cycle/DNA Damage >> ROCK Signaling Pathways >> Stem Cell/Wnt >> ROCK Signaling Pathways >> TGF-beta/Smad >> ROCK Research Areas >> Inflammation/Immunology
Target	ROCK2:1 μM (IC50)
In Vitro	Rho-associated protein kinase (ROCK) is a member of the serine-threonine protein kinase family. ROCK, which exists in two isoforms, ROCK1 and ROCK2, is an effector molecule of RhoA, and the RhoA/ROCK signaling pathway is involved in a number of cellular functions, which include, for example, actin organization, cell adhesion, cell migration, and cytokinesis. In addition, the RhoA/ROCK signaling pathway is involved in regulating smooth muscle contraction. Inhibitors of ROCK have been reported to be useful for treating multiple medical disorders, such as fibrosis, inflammatory disorders, autoimmune disorders, and cardiovascular disorders[1].
References	[1]. Aicher, Thomas Daniel, et al. INDAZOLYL THIADIAZOLAMINES AND RELATED COMPOUNDS FOR INHIBITION OF RHO-ASSOCIATED PROTEIN KINASE AND THE TREATMENT OF DISEASE. US20180093978A1.

Molecular Formula	C₁₈H₁₂N₆OS
Molecular Weight	360.39