2011708-43-1
2011708-43-1 structure
- Name: HER2-IN-2
- Chemical Name: HER2-IN-2
- CAS Number: 2011708-43-1
- Molecular Formula: C20H15N5O3
- Molecular Weight: 373.372
- Create Date: 2020-01-11 13:04:39
- Modify Date: 2024-07-24 18:41:26
-
HER2-IN-2 is a potent, selective HER2 inhibitor, only shows potent inhibition for EGFR and Abl in a panel of kinases; equipotent to lapatinib against HER2 in vitro, also able to inhibit the small amount of HER3 auto-phosphorylation; inhibits 2YF/3TM gatekeeper mutant Ba/F3 cells lines with IC50 of 18.63 nM.
| Name | HER2-IN-2 |
|---|
| Description | HER2-IN-2 is a potent, selective HER2 inhibitor, only shows potent inhibition for EGFR and Abl in a panel of kinases; equipotent to lapatinib against HER2 in vitro, also able to inhibit the small amount of HER3 auto-phosphorylation; inhibits 2YF/3TM gatekeeper mutant Ba/F3 cells lines with IC50 of 18.63 nM. |
|---|---|
| References | References 1. Novotny CJ, et al. Nat Chem Biol. 2016 Nov;12(11):923-930. View Related Products by Target EGFR |
| Molecular Formula | C20H15N5O3 |
|---|---|
| Molecular Weight | 373.372 |