TRAM 39

Modify Date: 2024-01-11 06:34:33

TRAM 39 structure	Common Name	TRAM 39
	CAS Number	197525-99-8	Molecular Weight	303.78500
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₀H₁₄ClN	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of TRAM 39

TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease[1][2][3][4].

Name	2-(2-chlorophenyl)-2,2-diphenylacetonitrile
Synonym	More Synonyms

Description	TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease[1][2][3][4].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel
Target	IC50: 60 nM (KCa3.1 channel)[4]
In Vitro	TRAM-39 (1 μM) reduces the peak amplitude of gKCa2 in sympathetic LAH neurons (mean percentage change 56%) in BAE cells[2]. TRAM-39 (200 nM) diminishes lipopolysaccharide (LPS)-induced cryptdin release from paneth cells[3].
In Vivo	TRAM-39 (1 μM; adds to the perfusate) fully blocks all IKCa channels in multicellular preparations[1].

Molecular Formula	C₂₀H₁₄ClN
Molecular Weight	303.78500
Exact Mass	303.08100
PSA	23.79000
LogP	5.19798
Storage condition	-20°C

(2-chlorophenyl)-diphenylacetonitrile

TRAM-39

TRAM 39

TRAM 39

Use of TRAM 39

Names

TRAM 39 Biological Activity

Chemical & Physical Properties

Synonyms