TRAM 39

Names

[ CAS No. ]:
197525-99-8

[ Name ]:
TRAM 39

[Synonym ]:
(2-chlorophenyl)-diphenylacetonitrile
TRAM-39
TRAM 39

Biological Activity

[Description]:

TRAM-39 is a selective blocker of intermediate conductance Ca2+-activated K+ (IKCa) channels. TRAM-39 inhibits KCa3.1 channel with an IC50 value of 60 nM. TRAM-39 can be used for the research of ataxia, epilepsy, memory disorders, schizophrenia and Parkinson’s disease[1][2][3][4].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> Membrane Transporter/Ion Channel >> Potassium Channel

[Target]

IC50: 60 nM (KCa3.1 channel)[4]

[In Vitro]

TRAM-39 (1 μM) reduces the peak amplitude of gKCa2 in sympathetic LAH neurons (mean percentage change 56%) in BAE cells[2]. TRAM-39 (200 nM) diminishes lipopolysaccharide (LPS)-induced cryptdin release from paneth cells[3].

[In Vivo]

TRAM-39 (1 μM; adds to the perfusate) fully blocks all IKCa channels in multicellular preparations[1].

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₁₄ClN

[ Molecular Weight ]:
303.78500

[ Exact Mass ]:
303.08100

[ PSA ]:
23.79000

[ LogP ]:
5.19798

[ Storage condition ]:
-20°C

Related Compounds

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