2132412-25-8

2132412-25-8 structure

Name: CI-39
Chemical Name: CI-39
CAS Number: 2132412-25-8
Molecular Formula: C₁₉H₁₈N₂O₄
Molecular Weight: 338.36
Catalog: Signaling Pathways Anti-infection HIV
Create Date: 2022-06-27 09:36:39
Modify Date: 2025-08-25 08:29:09
CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an EC50 of 3.40 µM and an CC50 of >30 µM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup[1].

Name	CI-39

Description	CI-39 is an antiviral natural product. CI-39 is an NNRTI (non-nucleoside reverse transcriptase inhibit) antiviral agent with an EC50 of 3.40 µM and an CC50 of >30 µM for wild type HIV-1. CI-39 inhibits HIV-1 RT DNA polymerase and ribonuclease H activitiessup[1].
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Research Areas >> Infection
Target	HIV-1 (WT):3.40 μM (EC50) HIV-1 (WT):>30 μM (CC50)
In Vitro	CI-39 (0-100 µM) inhibits HIV-1 RT DNA polymerase and ribonuclease H activities with EC50s of 7.20, >30 µM, respectively[1]. CI-39 shows antiviral activities with EC50s of 3.37, 3.00, 2.41, 3.08, 2.14, 3.27, 3.19, 4.07 µM for VSVG/HIV-1wt, VSVG/HIV-1RT-K103N, VSVG/HIV-1wtRT-K103N, VSVG/HIV-1RT-K1RT-Y181C, VSVG/HIV-1RT-K1RT-K103N,Y181C, VSVG/HIV-1RT-K103N,Y181C, VSVG/HIV-1RT-L100I,K103N, VSVG/HIV-1RT-Y188L, VSVG/HIV-1RT-K103N,G190A, VSVG/HIV-1RT-K103N,V108I, respectively[1].
References	[1]. Xu C, et al. Discovery, synthesis, and optimization of an N-alkoxy indolylacetamide against HIV-1 carrying NNRTI-resistant mutations from the Isatis indigotica root. Eur J Med Chem. 2020 Mar 1;189:112071.

Molecular Formula	C₁₉H₁₈N₂O₄
Molecular Weight	338.36