CX 614

Modify Date: 2024-01-14 15:56:48

CX 614 structure	Common Name	CX 614
	CAS Number	191744-13-5	Molecular Weight	247.24700
	Density	1.45g/cm3	Boiling Point	473.8ºC at 760 mmHg
	Molecular Formula	C₁₃H₁₃NO₄	Melting Point	N/A
	MSDS	N/A	Flash Point	240.3ºC

Use of CX 614

CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression[1][2].

Name	cx614
Synonym	More Synonyms

Description	CX614 is a positive variant modulator of AMPA receptors that enhances excitatory postsynaptic potentials (amplitude and duration) by blocking and slowing the inactivation of responses to glutamate and automatically evokes excitatory postsynaptic currents in neuronal cultures. CX614 can be used in the study of psychiatric disorders such as depression[1][2].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> iGluR Research Areas >> Neurological Disease Signaling Pathways >> Membrane Transporter/Ion Channel >> iGluR
In Vitro	CX614 (100 μM) 在 HEK293 细胞中，促进谷氨酸表观亲和力并增加谷氨酸诱发的内向电流，增加 3.5 和 10 mM 的谷氨酸反应峰值[1]。
In Vivo	CX614 (1 or 10 mg/kg, i.p., twice a day) 明显增加 P5 小鼠海马和皮层的 BDNF mRNA，证实了 AMPA 受体的正向异生调节剂对海马 BDNF mRNA 水平的上调作用[2]。
References	[1]. Wei Dai, et al. The Impact and Mechanism of a Novel Allosteric AMPA Receptor Modulator LCX001 on Protection Against Respiratory Depression in Rodents. Front Pharmacol. 2019 Feb 19;10:105. [2]. Eleni Dicou, et al. Positive allosteric modulators of AMPA receptors are neuroprotective against lesions induced by an NMDA agonist in neonatal mouse brain. Brain Res. 2003 Apr 25;970(1-2):221-5.

Density	1.45g/cm3
Boiling Point	473.8ºC at 760 mmHg
Molecular Formula	C₁₃H₁₃NO₄
Molecular Weight	247.24700
Flash Point	240.3ºC
Exact Mass	247.08400
PSA	48.00000
LogP	1.35020
Vapour Pressure	3.82E-09mmHg at 25°C
Index of Refraction	1.651
Storage condition	2-8°C

HS Code	2934999090

HS Code	2934999090
Summary	2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

CX 614

BDP 37

2,3,6a,7,8,9-Hexahydro-11H-1,4-dioxino[2,3-g]pyrrolo[2,1-b][1,3]benzoxazin-11-one

6a,7,8,9-Tetrahydro-2H-[1,4]dioxino[2',3':4,5]benzo[1,2-e]pyrrolo[2,1-b][1,3]oxazin-11(3H)-one

LiD 37

CX-614

DC Chemicals Limited
China
Product Name: CX-614
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/500mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 6A,7,8,9-TETRAHYDRO-2H-[1,4]DIOXINO[2',3':4,5]BENZO[1,2-E]PYRROLO[2,1-B][1,3]OXAZIN-11(3H)-ONE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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CX 614

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