CX 4338
Modify Date: 2024-01-12 10:24:41
CX 4338 structure
|
Common Name | CX 4338 | ||
|---|---|---|---|---|
| CAS Number | 41609-06-7 | Molecular Weight | 364.504 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 511.1±60.0 °C at 760 mmHg | |
| Molecular Formula | C22H24N2OS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 262.9±32.9 °C | |
| Symbol |
GHS09 |
Signal Word | Warning | |
Use of CX 4338CX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM; shows little to no inhibition of CXCR4-mediated β-arrestin-2 recruitment at 100 uM; inhibits receptor internalization, while enhancing CXCR2-mediated MAPK activation; inhibits CXCL8-induced chemotaxis in CXCR2-overexpressing cells and human neutrophils; significantly reduces neutrophils in bronchoalveolar lavage induced by LPS in mice. |
| Name | 2-(Benzylamino)-4,4-dimethyl-6-oxo-N-phenyl-1-cyclohexene-1-carbothioamide |
|---|---|
| Synonym | More Synonyms |
| Description | CX 4338 (CX4338, CX-4338) is a potent, selective CXCR2 inhibitor that selectively inhibits CXCR2-mediated recruitment of β-arrestin-2 with IC50 of 6.3 uM; shows little to no inhibition of CXCR4-mediated β-arrestin-2 recruitment at 100 uM; inhibits receptor internalization, while enhancing CXCR2-mediated MAPK activation; inhibits CXCL8-induced chemotaxis in CXCR2-overexpressing cells and human neutrophils; significantly reduces neutrophils in bronchoalveolar lavage induced by LPS in mice. |
|---|---|
| References | References 1. Ha H, et al. Br J Pharmacol. 2014 Mar;171(6):1551-65. View Related Products by Target Chemokine Receptor (CCR and CXCR) |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 511.1±60.0 °C at 760 mmHg |
| Molecular Formula | C22H24N2OS |
| Molecular Weight | 364.504 |
| Flash Point | 262.9±32.9 °C |
| Exact Mass | 364.160919 |
| LogP | 4.85 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.638 |
| MFCD00170629 |
| 1-Cyclohexene-1-carbothioamide, 4,4-dimethyl-6-oxo-N-phenyl-2-[(phenylmethyl)amino]- |
| 2-(benzylamino)-4,4-dimethyl-6-oxo-N-phenylcyclohex-1-ene-1-carbothioamide |
| 2-(Benzylamino)-4,4-dimethyl-6-oxo-N-phenyl-1-cyclohexene-1-carbothioamide |