PROTAC Linker 17

Modify Date: 2024-01-15 11:56:35

PROTAC Linker 17 Structure
PROTAC Linker 17 structure
Common Name PROTAC Linker 17
CAS Number 189209-27-6 Molecular Weight 380.47700
Density N/A Boiling Point N/A
Molecular Formula C17H36N2O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of PROTAC Linker 17


PROTAC Linker 17 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 17 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

 Names

Name tert-butyl N-[2-[2-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethyl]carbamate
Synonym More Synonyms

 PROTAC Linker 17 Biological Activity

Description PROTAC Linker 17 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 17 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
Related Catalog
Target

Alkyl/ether

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C17H36N2O7
Molecular Weight 380.47700
Exact Mass 380.25200
PSA 113.99000
LogP 1.45750

 Safety Information

Hazard Codes Xi

 Synthetic Route

~99%

PROTAC Linker 17 Structure

PROTAC Linker 17

CAS#:189209-27-6

Literature: Gerard, Estelle; Meulle, Aline; Feron, Olivier; Marchand-Brynaert, Jacqueline Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 1 p. 586 - 590

~%

PROTAC Linker 17 Structure

PROTAC Linker 17

CAS#:189209-27-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 586 - 590

~%

PROTAC Linker 17 Structure

PROTAC Linker 17

CAS#:189209-27-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 586 - 590

~%

PROTAC Linker 17 Structure

PROTAC Linker 17

CAS#:189209-27-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 586 - 590

~%

PROTAC Linker 17 Structure

PROTAC Linker 17

CAS#:189209-27-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 586 - 590

~%

PROTAC Linker 17 Structure

PROTAC Linker 17

CAS#:189209-27-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 586 - 590

~%

PROTAC Linker 17 Structure

PROTAC Linker 17

CAS#:189209-27-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 586 - 590

~%

PROTAC Linker 17 Structure

PROTAC Linker 17

CAS#:189209-27-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 586 - 590

~%

PROTAC Linker 17 Structure

PROTAC Linker 17

CAS#:189209-27-6

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 22, # 1 p. 586 - 590

 Synonyms

19-Amino-5,8,11,14,17-pentaoxa-2-azanonadecanoic Acid 1,1-Dimethylethyl Ester
Boc-NH-PEG5-CH2CH2NH2
t-boc-N-amido-PEG5-Amine
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