PROTAC Linker 17

Names

[ Name ]:
PROTAC Linker 17

[Synonym ]:
19-Amino-5,8,11,14,17-pentaoxa-2-azanonadecanoic Acid 1,1-Dimethylethyl Ester
Boc-NH-PEG5-CH2CH2NH2
t-boc-N-amido-PEG5-Amine

Biological Activity

[Description]:

PROTAC Linker 17 is a PROTAC linker, which refers to the alkyl/ether composition. PROTAC Linker 17 can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

Alkyl/ether

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₃₆N₂O₇

[ Molecular Weight ]:
380.47700

[ Exact Mass ]:
380.25200

[ PSA ]:
113.99000

[ LogP ]:
1.45750

Safety Information

[ Hazard Codes ]:
Xi

PROTAC Linker 17

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

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Related Compounds