β-catenin-IN-11a
Modify Date: 2023-01-17 11:20:25
β-catenin-IN-11a structure
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Common Name | β-catenin-IN-11a | ||
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| CAS Number | 1884472-26-7 | Molecular Weight | 504.59 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H28N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of β-catenin-IN-11aβ-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex; blocks the cell cycle inhibitory effect of CD44 and induces cell accumulation of CD44 high cells in cycling phase in S, G2 and M phase, leads to inhibition of embryonic transcriptional factor Nanog but not Sox2 or Oct-4 in colon cancer cells. |
| Name | β-catenin-IN-11a |
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| Description | β-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex; blocks the cell cycle inhibitory effect of CD44 and induces cell accumulation of CD44 high cells in cycling phase in S, G2 and M phase, leads to inhibition of embryonic transcriptional factor Nanog but not Sox2 or Oct-4 in colon cancer cells. |
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| References | References 1. Radwan AA, et al. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1664-70. View Related Products by Target Beta-catenin |
| Molecular Formula | C31H28N4O3 |
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| Molecular Weight | 504.59 |