β-catenin inhibitor C2
Modify Date: 2025-08-25 12:36:21
β-catenin inhibitor C2 structure
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Common Name | β-catenin inhibitor C2 | ||
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| CAS Number | 1005288-15-2 | Molecular Weight | 484.25 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C19H20Br2N2Os | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of β-catenin inhibitor C2β-catenin inhibitor C2 is a novel potent selective β-catenin inhibitor with Kd of 54.96 nM, directly to ARM domain of β-catenin.β-catenin inhibitor C2 reduced viability of DLD1 and SW480 cells in dose-dependent manner with IC50 ranging between 0.8-1.3 uM, viability of HCT116 and SW48 with IC50 3.45-5.35 uM.β-catenin inhibitor C2 selectively inhibits β-catenin, lowers its cellular load and significantly reduces viability of β-catenin-driven cancer cells. |
| Name | β-catenin inhibitor C2 |
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| Description | β-catenin inhibitor C2 is a novel potent selective β-catenin inhibitor with Kd of 54.96 nM, directly to ARM domain of β-catenin.β-catenin inhibitor C2 reduced viability of DLD1 and SW480 cells in dose-dependent manner with IC50 ranging between 0.8-1.3 uM, viability of HCT116 and SW48 with IC50 3.45-5.35 uM.β-catenin inhibitor C2 selectively inhibits β-catenin, lowers its cellular load and significantly reduces viability of β-catenin-driven cancer cells. |
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| References | 1. Anton Cheltsov, et al. Sci Rep. 2020 May 15;10(1):8096. |
| Molecular Formula | C19H20Br2N2Os |
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| Molecular Weight | 484.25 |
| InChIKey | VPOJWIBWEJWBKC-SNAWJCMRSA-N |
| SMILES | Oc1c(Br)cc(Br)cc1C=CNC(=S)NC1CC2CC1C1C=CCC21 |