β-catenin-IN-11a
Names
[ CAS No. ]:
1884472-26-7
[ Name ]:
β-catenin-IN-11a
Biological Activity
[Description]:
β-catenin-IN-11a is a β-catenin/CD44/Nanog axis inhibitor, docks into the β-catenin allosteric site and interferes β-catenin/TCF-4 complex; blocks the cell cycle inhibitory effect of CD44 and induces cell accumulation of CD44 high cells in cycling phase in S, G2 and M phase, leads to inhibition of embryonic transcriptional factor Nanog but not Sox2 or Oct-4 in colon cancer cells.
[References]
References 1. Radwan AA, et al. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1664-70. View Related Products by Target Beta-catenin
Chemical & Physical Properties
[ Molecular Formula ]:
C31H28N4O3
[ Molecular Weight ]:
504.59