Mito-TRFS

Modify Date: 2024-01-14 12:14:51

Mito-TRFS Structure
Mito-TRFS structure
Common Name Mito-TRFS
CAS Number 1859102-62-7 Molecular Weight 820.70
Density N/A Boiling Point N/A
Molecular Formula C38H34IN2O5PS2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mito-TRFS


Mito-TRFS, the first off-on probe, is used to image the mitochondrial thioredoxin reductase (TrxR2) in live cells[1].

 Names

Name Mito-TRFS

 Mito-TRFS Biological Activity

Description Mito-TRFS, the first off-on probe, is used to image the mitochondrial thioredoxin reductase (TrxR2) in live cells[1].
Related Catalog
In Vitro Mito-TRFS (10 μM) has the maximal absorption at ~375 nm in TE buffer (50 mM Tris-HCl and 1 mM EDTA, pH 7.4) at 37 °C[1]. Mito-TRFS itself has a strong emission at ~480 nm when excited at 375 nm in TE buffer (φ=0.34), but has weak emission when excited at 438 nm[1]. Immunofluorescence[1]. Cell Line: HeLa cells. Concentration: 1 μM. Incubation Time: 2 h. Result: Mito-TRFS is localized predominantly in the mitochondria of live cells.
References

[1]. Yaping Liu, et al. A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model. Chem Commun (Camb). 2016 Feb 7;52(11):2296-9.

 Chemical & Physical Properties

Molecular Formula C38H34IN2O5PS2
Molecular Weight 820.70