Heat Shock Protein Inhibitor II

Modify Date: 2023-01-13 17:07:46

Heat Shock Protein Inhibitor II structure	Common Name	Heat Shock Protein Inhibitor II
	CAS Number	1859-42-3	Molecular Weight	217.22
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₂H₁₁NO₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Heat Shock Protein Inhibitor II

KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research[1][2].

Name	3-benzo[1,3]dioxol-5-ylmethylene-pyrrolidin-2-one
Synonym	More Synonyms

Description	KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
References	[1]. Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7(1):215-9. [2]. Blatzer M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015 Jul;59(7):3778-88.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> HSP

Research Areas >> Infection

Signaling Pathways >> Cell Cycle/DNA Damage >> HSP

References

[1]. Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7(1):215-9.

[2]. Blatzer M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015 Jul;59(7):3778-88.