1859-42-3

1859-42-3 structure

Name: Heat Shock Protein Inhibitor II
Chemical Name: 3-benzo[1,3]dioxol-5-ylmethylene-pyrrolidin-2-one
CAS Number: 1859-42-3
Molecular Formula: C₁₂H₁₁NO₃
Molecular Weight: 217.22
Catalog: Signaling Pathways Cell Cycle/DNA Damage HSP
Create Date: 2017-11-15 09:03:12
Modify Date: 2025-08-25 17:23:49
KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research[1][2].

Name	3-benzo[1,3]dioxol-5-ylmethylene-pyrrolidin-2-one
Synonyms	2-oxo-3-piperonyliden-pyrrolidin HEAT SHOCK PROTEIN INHIBITOR II 3,4-methylenedioxy-benzylidine-γ-butyrolactam

Description	KNK423 is a specific heat shock protein (HSP) synthesis inhibitor. KNK423 improves the efficiency of Amphotericin B in inhibiting resistant Aspergillus terreus by blocking HSP70. KNK423 can be used in cancer and bacterial infection research[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> HSP Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> HSP
References	[1]. Koishi M, et al. The effects of KNK437, a novel inhibitor of heat shock protein synthesis, on the acquisition of thermotolerance in a murine transplantable tumor in vivo. Clin Cancer Res. 2001 Jan;7(1):215-9. [2]. Blatzer M, et al. Blocking Hsp70 enhances the efficiency of amphotericin B treatment against resistant Aspergillus terreus strains. Antimicrob Agents Chemother. 2015 Jul;59(7):3778-88.