Br-PBTC
Modify Date: 2024-01-23 16:57:47
Br-PBTC structure
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Common Name | Br-PBTC | ||
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| CAS Number | 1839519-57-1 | Molecular Weight | 339.25 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C14H15BrN2OS | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Br-PBTCBr-PBTC is a potent, 2/4 subtype-selective positive allosteric modulator of nAChRs (nicotinic acetylcholine receptors) with α2β2，α2β4，α4β2，α4β4，(α4β2)2α4 and (α4β2)2β2 EC50 ranges from 0.1~0.6 μM. Br-PBTC acts from the c-tail of an α subunit[1]. |
| Name | Br-PBTC |
|---|
| Description | Br-PBTC is a potent, 2/4 subtype-selective positive allosteric modulator of nAChRs (nicotinic acetylcholine receptors) with α2β2，α2β4，α4β2，α4β4，(α4β2)2α4 and (α4β2)2β2 EC50 ranges from 0.1~0.6 μM. Br-PBTC acts from the c-tail of an α subunit[1]. |
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| Related Catalog | |
| Target |
nAChRs[1] |
| In Vitro | Br-PBTC (0.01~10 μM; HEK cells) selectively affects 2 and 4 subunits. Br-PBTC (3 μM; oocytes) has greater effects on nAChRs with 2 subunits over those with 4 subunits. Br-PBTC (0.01~10 μM; 15 minutes; HEK cells) can increase channel activation by a maximal concentration of ACh. Br-PBTC (3 μM; 50 seconds; oocytes) increased ACh activation of α4β2 nAChRs by 385± 61 %. Br-PBTC (3 μM；oocytes) reactivates short term desensitized nAChRs expressed. Br-PBTC (3 μM; 500 seconds; HEK cells) reactivates short term desensitized (α4β2)2α4 and(α4β2)2β2 nAChRs expressed. Br-PBTC (0.1~100 μM；0~140 seconds; HEK cells) reactivates long term desensitized nAChRs[1]. |
| References |
| Molecular Formula | C14H15BrN2OS |
|---|---|
| Molecular Weight | 339.25 |