Desmethyl Erlotinib
Modify Date: 2025-08-25 11:22:16
Desmethyl Erlotinib structure
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Common Name | Desmethyl Erlotinib | ||
|---|---|---|---|---|
| CAS Number | 183321-86-0 | Molecular Weight | 379.409 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 572.8±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H21N3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 300.2±30.1 °C | |
Use of Desmethyl ErlotinibDesmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1]. |
| Name | 2-({4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl }oxy)ethanol |
|---|---|
| Synonym | More Synonyms |
| Description | Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1]. |
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| Related Catalog | |
| In Vivo | Desmethyl Erlotinib exhibits t1/2 of 11.96±2.01 h in a pharmacokinetic study in Wistar rats[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 572.8±50.0 °C at 760 mmHg |
| Molecular Formula | C21H21N3O4 |
| Molecular Weight | 379.409 |
| Flash Point | 300.2±30.1 °C |
| Exact Mass | 379.153198 |
| PSA | 85.73000 |
| LogP | 1.75 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.644 |
| InChIKey | KOQIAZNBAWFSQM-UHFFFAOYSA-N |
| SMILES | C#Cc1cccc(Nc2ncnc3cc(OCCOC)c(OCCO)cc23)c1 |
| 2-({4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl}oxy)ethanol |
| Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]- |
| Desmethyl Erlotinib |