OSI-420
Modify Date: 2024-01-02 17:58:40
OSI-420 structure
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Common Name | OSI-420 | ||
|---|---|---|---|---|
| CAS Number | 183320-51-6 | Molecular Weight | 415.870 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H22ClN3O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of OSI-420Desmethyl Erlotinib (OSI-420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor. |
| Name | 2-[4-(3-ethynylanilino)-7-(2-methoxyethoxy)quinazolin-6-yl]oxyethanol,hydrochloride |
|---|---|
| Synonym | More Synonyms |
| Description | Desmethyl Erlotinib (OSI-420) is an active metabolite of erlotinib, which is a potent EGFR tyrosin kinase inhibitor. |
|---|---|
| Related Catalog | |
| In Vivo | Desmethyl Erlotinib exposure (AUC) in plasma is 30% (range 12-59%) of erlotinib, and Desmethyl Erlotinib clearance is more than 5-fold higher than erlotinib. The CSF penetration of erlotinib and Desmethyl Erlotinib is <5% relative to total plasma concentration[1]. |
| References |
| Molecular Formula | C21H22ClN3O4 |
|---|---|
| Molecular Weight | 415.870 |
| Exact Mass | 415.129883 |
| PSA | 85.73000 |
| LogP | 3.62600 |
| Storage condition | -20℃ |
| OSI-420 |
| 2-({4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl}oxy)ethanol hydrochloride (1:1) |
| Desmethyl erlotinib hydrochloride |
| Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]-, hydrochloride (1:1) |
| S2205_Selleck |
| Desmethyl Erlotinib |
| Erlotinib Impurity 4 |