Desmethyl Erlotinib-d4

Modify Date: 2024-01-10 15:49:43

Desmethyl Erlotinib-d4 Structure
Desmethyl Erlotinib-d4 structure
Common Name Desmethyl Erlotinib-d4
CAS Number 1216420-11-9 Molecular Weight 383.43
Density N/A Boiling Point N/A
Molecular Formula C21H17D4N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Desmethyl Erlotinib-d4


Desmethyl Erlotinib-d4 (OSI-420-d4 free base) is the deuterium labeled Desmethyl Erlotinib. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1][2].

 Names

Name Desmethyl Erlotinib-d4

 Desmethyl Erlotinib-d4 Biological Activity

Description Desmethyl Erlotinib-d4 (OSI-420-d4 free base) is the deuterium labeled Desmethyl Erlotinib. Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. Thappali SR, et al. Simultaneous Determination of Celecoxib, Erlotinib, and its Metabolite Desmethyl-Erlotinib (OSI-420) in Rat Plasma by Liquid chromatography/Tandem Mass Spectrometry with Positive/Negative Ion-Switching Electrospray Ionisation.Sci Pharm. 2012 Jul-Sep;80(3):633-46.

 Chemical & Physical Properties

Molecular Formula C21H17D4N3O4
Molecular Weight 383.43