183321-86-0
183321-86-0 structure
- Name: Desmethyl Erlotinib
- Chemical Name: 2-({4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl }oxy)ethanol
- CAS Number: 183321-86-0
- Molecular Formula: C21H21N3O4
- Molecular Weight: 379.409
- Create Date: 2018-05-22 08:00:00
- Modify Date: 2025-08-25 11:22:16
-
Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1].
| Name | 2-({4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl }oxy)ethanol |
|---|---|
| Synonyms |
2-({4-[(3-Ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl}oxy)ethanol
Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]- Desmethyl Erlotinib |
| Description | Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib. Erlotinib is a potent EGFR tyrosin kinase inhibitor[1]. |
|---|---|
| Related Catalog | |
| In Vivo | Desmethyl Erlotinib exhibits t1/2 of 11.96±2.01 h in a pharmacokinetic study in Wistar rats[1]. |
| References |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 572.8±50.0 °C at 760 mmHg |
| Molecular Formula | C21H21N3O4 |
| Molecular Weight | 379.409 |
| Flash Point | 300.2±30.1 °C |
| Exact Mass | 379.153198 |
| PSA | 85.73000 |
| LogP | 1.75 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.644 |