MLT-748

Modify Date: 2023-01-21 19:29:58

MLT-748 structure	Common Name	MLT-748
	CAS Number	1832578-30-9	Molecular Weight	492.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₉H₁₉Cl₂N₉O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of MLT-748

MLT-748 is an allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM. MLT-748 also reversibly binds to human mutant MALT1(329-728)-W580S (Kd, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (Kd, 42 nM)[1].

Name	MLT-748

Description	MLT-748 is an allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM. MLT-748 also reversibly binds to human mutant MALT1(329-728)-W580S (Kd, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (Kd, 42 nM)[1].
Related Catalog	Signaling Pathways >> NF-κB >> MALT1 Research Areas >> Inflammation/Immunology
Target	IC50: 5 nM (MALT1)[1] Kd: 13 nM (MALT1(329-728)-W580S), 42 nM (MALT1(329-728))[1]
References	[1]. Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15(3):304-313.

Molecular Formula	C₁₉H₁₉Cl₂N₉O₃
Molecular Weight	492.32
Storage condition	-20°C

Hazard Codes	Xn

DC Chemicals Limited
China
Product Name: MLT-748
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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