1832577-07-7

1832577-07-7 structure

Name: (R)-MLT-985
Chemical Name: (R)-MLT-985
CAS Number: 1832577-07-7
Molecular Formula: C₁₇H₁₅Cl₂N₉O₂
Molecular Weight: 448.27
Catalog: Signaling Pathways NF-κB MALT1
Create Date: 2022-05-20 22:11:25
Modify Date: 2024-01-09 15:13:46
(R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC50 of 3 nM. (R)-MLT-985 has an IC50 of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells[1].

Name	(R)-MLT-985

Description	(R)-MLT-985 (compound 11) is a potent MALT1 protease inhibitor with an IC50 of 3 nM. (R)-MLT-985 has an IC50 of 20 nM for MALT1-dependent IL-2 production in Jurkat cells. (R)-MLT-985 suppresses growth and aberrant CARD11/BCL10/MALT1 complex signaling in ABC-DLBCL cells[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> NF-κB >> MALT1
References	[1]. Jean Quancard, et al. Optimization of the In Vivo Potency of Pyrazolopyrimidine MALT1 Protease Inhibitors by Reducing Metabolism and Increasing Potency in Whole Blood. J Med Chem. 2020 Dec 10;63(23):14594-14608.

Molecular Formula	C₁₇H₁₅Cl₂N₉O₂
Molecular Weight	448.27