2097853-86-4

2097853-86-4 structure

Name: MLT-747
Chemical Name: MLT-747
CAS Number: 2097853-86-4
Molecular Formula: C₂₀H₂₁Cl₂N₇O₃
Molecular Weight: 478.33
Catalog: Signaling Pathways NF-κB MALT1
Create Date: 2019-03-30 12:14:34
Modify Date: 2024-01-10 11:14:31
MLT-748 is a allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM. MLT-748 also reversibly binds to human mutant MALT1(329-728)-W580S (Kd, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (Kd, 42 nM)[1].

Name	MLT-747

Description	MLT-748 is a allosteric inhibitor of MALT1, binds MALT1 in the allosteric Trp580 pocket, with an IC50 of 5 nM. MLT-748 also reversibly binds to human mutant MALT1(329-728)-W580S (Kd, 13 nM) with affinity similar to that of the wild type MALT1(329-728) (Kd, 42 nM)[1].
Related Catalog	Signaling Pathways >> NF-κB >> MALT1 Research Areas >> Inflammation/Immunology
Target	IC50: 5 nM (MALT1)[1] Kd: 13 nM (MALT1(329-728)-W580S), 42 nM (MALT1(329-728))[1]
References	[1]. Quancard J, et al. An allosteric MALT1 inhibitor is a molecular corrector rescuing function in an immunodeficient patient. Nat Chem Biol. 2019 Mar;15(3):304-313.

Molecular Formula	C₂₀H₂₁Cl₂N₇O₃
Molecular Weight	478.33