LY320135
Modify Date: 2024-01-10 22:13:36
LY320135 structure
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Common Name | LY320135 | ||
|---|---|---|---|---|
| CAS Number | 176977-56-3 | Molecular Weight | 383.39600 | |
| Density | 1.31g/cm3 | Boiling Point | 617.2ºC at 760mmHg | |
| Molecular Formula | C24H17NO4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 327.1ºC | |
| Symbol |
GHS06 |
Signal Word | Danger | |
Use of LY320135LY320135 is a potent and selective antagonist of CB1 receptor, with a Ki of 141 nM. LY320135 also binds to 5-HT2 and muscarinic receptors with Kis of 6.4 μM and 2.1 μM, respectively. LY320135 exhibits neuroprotective effect[1][2]. |
| Name | 4-[6-methoxy-2-(4-methoxyphenyl)-1-benzofuran-3-carbonyl]benzonitrile |
|---|---|
| Synonym | More Synonyms |
| Description | LY320135 is a potent and selective antagonist of CB1 receptor, with a Ki of 141 nM. LY320135 also binds to 5-HT2 and muscarinic receptors with Kis of 6.4 μM and 2.1 μM, respectively. LY320135 exhibits neuroprotective effect[1][2]. |
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| Related Catalog | |
| Target |
CB1:141 nM (Ki) 5-HT2 Receptor:6.4 μM (Ki) muscarinic receptor:2.1 μM (Ki) CB2:>10 μM (Ki) |
| In Vitro | LY320135 has a relatively low affinity for the CB2 receptor (Ki=14.9±0.4 μM) and ten other unrelated receptors[1]. LY320135 (1 nM-10 μM) inhibits the anandamide-mediated forskolin-stimulated cAMP accumulation in CHO cell, with an IC50 of 734±122 nM[1]. LY320135 (0.1-1000 nM; 1-8 min) can reverse calcium current (ICa) inhibition by WIN 55212-2 in N18 cells, with an IC50 of 55±10 nM[1]. LY320135 (1 μM) prevents activation of Kir current by WIN 55212-2 in AtT-20-CB1 cells[1]. LY 320135 (0.001-1 μM) reduces CA1 injury induced by 20 min oxygen-glucose deprivation (OGD) in a concentration-dependent manner[2]. |
| References |
| Density | 1.31g/cm3 |
|---|---|
| Boiling Point | 617.2ºC at 760mmHg |
| Molecular Formula | C24H17NO4 |
| Molecular Weight | 383.39600 |
| Flash Point | 327.1ºC |
| Exact Mass | 383.11600 |
| PSA | 72.46000 |
| LogP | 5.21968 |
| Vapour Pressure | 3.64E-15mmHg at 25°C |
| Index of Refraction | 1.664 |
| Storage condition | 2-8°C |
| Symbol |
GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | P301 + P310 |
| RIDADR | UN 2811 6.1 / PGIII |
| HS Code | 2932999099 |
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Biased Agonism and Biased Allosteric Modulation at the CB1 Cannabinoid Receptor.
Mol. Pharmacol. 88 , 368-79, (2015) CB1 cannabinoid receptors (CB1Rs) are attractive therapeutic targets for numerous central nervous system disorders. However, clinical application of cannabinoid ligands has been hampered owing to thei... |
| MFCD00945878 |