Monensin

Modify Date: 2024-01-04 12:14:25

Monensin Structure
Monensin structure
Common Name Monensin
CAS Number 17090-79-8 Molecular Weight 670.871
Density 1.2±0.1 g/cm3 Boiling Point 766.3±60.0 °C at 760 mmHg
Molecular Formula C36H61NaO11 Melting Point 103-105°C
MSDS N/A Flash Point 229.2±26.4 °C

 Use of Monensin


Monensin is a lipid-soluble naturally occurring bioactive ionophore produced by Streptomyces spp. Monensin can bind protons and monovalent cations. Monensin exhibits a broad spectrum activity against opportunistic pathogens of humans in both drug sensitive and resistant strains. Monensin also induces apoptosis in multiple cancer cell lines[1][2].

 Names

Name monensin A
Synonym More Synonyms

 Monensin Biological Activity

Description Monensin is a lipid-soluble naturally occurring bioactive ionophore produced by Streptomyces spp. Monensin can bind protons and monovalent cations. Monensin exhibits a broad spectrum activity against opportunistic pathogens of humans in both drug sensitive and resistant strains. Monensin also induces apoptosis in multiple cancer cell lines[1][2].
Related Catalog
References

[1]. Rajendran V, et, al. Chemotherapeutic Potential of Monensin as an Anti-microbial Agent. Curr Top Med Chem. 2018; 18(22): 1976-1986.

[2]. Vanneste M, et, al. High content screening identifies monensin as an EMT-selective cytotoxic compound. Sci Rep. 2019 Feb 4; 9(1):1200.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 766.3±60.0 °C at 760 mmHg
Melting Point 103-105°C
Molecular Formula C36H61NaO11
Molecular Weight 670.871
Flash Point 229.2±26.4 °C
Exact Mass 670.429199
PSA 156.20000
LogP 3.72
Vapour Pressure 0.0±5.9 mmHg at 25°C
Index of Refraction 1.546
Storage condition 2-8°C

 Safety Information

Hazard Codes T: Toxic;
Risk Phrases R25
Safety Phrases S36/37/39-S45
RIDADR UN 3462 6.1/PG 2
WGK Germany 3
RTECS JH2830000
Packaging Group II
Hazard Class 6.1(a)

 Synonyms

1,6-Dioxaspiro[4.5]decane-7-butanoic acid, 2-[(2S,2'R,3'S,5R,5'R)-2-ethyloctahydro-3'-methyl-5'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-9- ;hydroxy-β-methoxy-α,γ,2,8-tetramethyl-, (αS,βR,γS,2S,5R,7S,8R,9S)-
monensicacid
Monensin
Elancoban
Monelan
Romensin
MONENSIN SODIUM
1,6-dioxaspiro[4.5]decane-7-butanoic acid, 2-[(2S,2'R,3'S,5R,5'R)-2-ethyloctahydro-3'-methyl-5'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-9-hydroxy-b-methoxy-a,g,2,8-tetramethyl-, (aS,bR,gS,2S,5R,7S,8R,9S)-
MONENSIN(PURE)
MFCD00077826
EINECS 244-941-7
a3823a
1,6-dioxaspiro[4.5]decane-7-butanoic acid, 2-[(2S,2'R,3'S,5R,5'R)-2-ethyloctahydro-3'-methyl-5'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-, (αS,βR,γS,2S,5R,7S,8R,9S)-
(2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-{(2S,2'R,3'S,5R,5'R)-2-Ethyl-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-3'-methyloctahydro-2,2'-bifuran-5-yl}-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methylpentanoic acid
MONENSIN NA