Monensin

Names

[ Name ]:
Monensin

[Synonym ]:
1,6-Dioxaspiro[4.5]decane-7-butanoic acid, 2-[(2S,2'R,3'S,5R,5'R)-2-ethyloctahydro-3'-methyl-5'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-9- ;hydroxy-β-methoxy-α,γ,2,8-tetramethyl-, (αS,βR,γS,2S,5R,7S,8R,9S)-
monensicacid
Monensin
Elancoban
Monelan
Romensin
MONENSIN SODIUM
1,6-dioxaspiro[4.5]decane-7-butanoic acid, 2-[(2S,2'R,3'S,5R,5'R)-2-ethyloctahydro-3'-methyl-5'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-9-hydroxy-b-methoxy-a,g,2,8-tetramethyl-, (aS,bR,gS,2S,5R,7S,8R,9S)-
MONENSIN(PURE)
MFCD00077826
EINECS 244-941-7
a3823a
1,6-dioxaspiro[4.5]decane-7-butanoic acid, 2-[(2S,2'R,3'S,5R,5'R)-2-ethyloctahydro-3'-methyl-5'-[(2S,3S,5R,6R)-tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl][2,2'-bifuran]-5-yl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-, (αS,βR,γS,2S,5R,7S,8R,9S)-
(2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-{(2S,2'R,3'S,5R,5'R)-2-Ethyl-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-3'-methyloctahydro-2,2'-bifuran-5-yl}-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methylpentanoic acid
MONENSIN NA

Biological Activity

[Description]:

Monensin is a lipid-soluble naturally occurring bioactive ionophore produced by Streptomyces spp. Monensin can bind protons and monovalent cations. Monensin exhibits a broad spectrum activity against opportunistic pathogens of humans in both drug sensitive and resistant strains. Monensin also induces apoptosis in multiple cancer cell lines[1][2].

[Related Catalog]:

Signaling Pathways >> Apoptosis >> Apoptosis

Research Areas >> Cancer

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[References]

[1]. Rajendran V, et, al. Chemotherapeutic Potential of Monensin as an Anti-microbial Agent. Curr Top Med Chem. 2018; 18(22): 1976-1986.

[2]. Vanneste M, et, al. High content screening identifies monensin as an EMT-selective cytotoxic compound. Sci Rep. 2019 Feb 4; 9(1):1200.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
766.3±60.0 °C at 760 mmHg

[ Melting Point ]:
103-105°C

[ Molecular Formula ]:
C₃₆H₆₁NaO₁₁

[ Molecular Weight ]:
670.871

[ Flash Point ]:
229.2±26.4 °C

[ Exact Mass ]:
670.429199

[ PSA ]:
156.20000

[ LogP ]:
3.72

[ Vapour Pressure ]:
0.0±5.9 mmHg at 25°C

[ Index of Refraction ]:
1.546

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S36/37/39-S45

[ RIDADR ]:
UN 3462 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
JH2830000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Precursor & DownStream

Precursor

DownStream

Related Compounds

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