BACE2-IN-1

Modify Date: 2024-04-11 16:54:08

BACE2-IN-1 structure	Common Name	BACE2-IN-1
	CAS Number	1676107-08-6	Molecular Weight	617.70
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₆H₃₈F₃N₃O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of BACE2-IN-1

BACE2-IN-1 (compound 3l) is a highly selective BACE2 inhibitor with a Ki value of 1.6 nM. BACE2 inhibitors can be used to research of Type 2 Diabetes[1].

Name	BACE2-IN-1

Description	BACE2-IN-1 (compound 3l) is a highly selective BACE2 inhibitor with a Ki value of 1.6 nM. BACE2 inhibitors can be used to research of Type 2 Diabetes[1].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> Beta-secretase Research Areas >> Metabolic Disease
Target	BACE2:1.6 nM (Ki) BACE1:815.1 nM (Ki)
In Vitro	BACE2-IN-1 (compound 3l) inhibits BACE2 with an Ki value of 1.6 nM, 500 fold over BACE1 (Ki = 815.1 nM)[1].
References	[1]. Ghosh AK, et al. Highly Selective and Potent Human β-Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X-ray Structure and Structure-Activity Relationship Studies. ChemMedChem. 2019 Mar 5. 14(5):545-560.

Molecular Formula	C₃₆H₃₈F₃N₃O₃
Molecular Weight	617.70
InChIKey	KQGVKXJLEHXBDS-CBHGIOBQSA-N
SMILES	Cc1cc(C(=O)NC(Cc2ccccc2)C(O)CNCc2cccc(C(F)(F)F)c2)cc(C(=O)N(C)C(C)c2ccccc2)c1

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