Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt

Modify Date: 2024-01-05 13:55:39

Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt structure	Common Name	Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt
	CAS Number	167114-91-2	Molecular Weight	1822.12000
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₆₄H₁₁₆N₂₂O₁₉	Melting Point	N/A
	MSDS	USA	Flash Point	N/A

Use of Autocamtide-2-Related Inhibitory Peptide trifluoroacetate salt

Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.

Name	Autocamtide 2-related inhibitory peptide
Synonym	More Synonyms

Description	Autocamtide-2-related inhibitory peptide is a highly specific and potent inhibitor of CaMKII with an IC50 of 40 nM.
Related Catalog	Signaling Pathways >> Neuronal Signaling >> CaMK Signaling Pathways >> Autophagy >> Autophagy Research Areas >> Neurological Disease
Target	IC50: 40 nM (CaMKII)[1].
In Vitro	It is found that Autocamtide-2-related inhibitory peptide (a novel synthetic peptide ATP) is a potent inhibitor of CaM-kinase II with an IC50 of 40 nM, which is active in the presence or absence of Ca2+/calmodulin. It is 50 and 500 times more potent than CaMK-(281-302Ala286) and KN-93,respectively, under the assay condition used[1].
References	[1]. Ishida A, et al. A novel highly specific and potent inhibitor of calmodulin-dependent protein kinase II. Biochem Biophys Res Commun. 1995 Jul 26;212(3):806-12.

Molecular Formula	C₆₄H₁₁₆N₂₂O₁₉
Molecular Weight	1822.12000
Exact Mass	1821.07000
PSA	746.43000
LogP	8.46970

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn: Harmful;
Risk Phrases	20/21/22-36
Safety Phrases	22-24/25-26
RIDADR	NONH for all modes of transport

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AIP [Ala9]-Autocamtide 2

Autocamtide-2-related inhibitory peptide