PF-04781340
Modify Date: 2024-03-04 06:24:16
PF-04781340 structure
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Common Name | PF-04781340 | ||
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| CAS Number | 1648726-56-0 | Molecular Weight | 267.376 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C17H21N3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PF-04781340A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability; displays >150-fold selectivity over 5-HT2B receptors agonism (EC50=1484 nM); exhibits good metabolic stability in human liver microsomes (HLM) and moderate to good passive permeability in RRCK cells. |
| Name | PF-04781340 |
|---|
| Description | A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability; displays >150-fold selectivity over 5-HT2B receptors agonism (EC50=1484 nM); exhibits good metabolic stability in human liver microsomes (HLM) and moderate to good passive permeability in RRCK cells. |
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| References | References 1. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8. View Related Products by Target 5-HT Receptor |
| Molecular Formula | C17H21N3 |
|---|---|
| Molecular Weight | 267.376 |