1648726-56-0
1648726-56-0 structure
- Name: PF-04781340
- Chemical Name: PF-04781340
- CAS Number: 1648726-56-0
- Molecular Formula: C17H21N3
- Molecular Weight: 267.376
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2020-01-20 19:18:57
- Modify Date: 2024-03-04 06:24:16
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A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability; displays >150-fold selectivity over 5-HT2B receptors agonism (EC50=1484 nM); exhibits good metabolic stability in human liver microsomes (HLM) and moderate to good passive permeability in RRCK cells.
| Name | PF-04781340 |
|---|
| Description | A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability; displays >150-fold selectivity over 5-HT2B receptors agonism (EC50=1484 nM); exhibits good metabolic stability in human liver microsomes (HLM) and moderate to good passive permeability in RRCK cells. |
|---|---|
| References | References 1. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8. View Related Products by Target 5-HT Receptor |
| Molecular Formula | C17H21N3 |
|---|---|
| Molecular Weight | 267.376 |