PF-04781340

Names

[ Name ]:
PF-04781340

Biological Activity

[Description]:

A potent, selective, CNS penetrant 5-HT2C receptor agonist with Ki of 3 nM and EC50 of 9 nM, without significant P-gp efflux liability; displays >150-fold selectivity over 5-HT2B receptors agonism (EC50=1484 nM); exhibits good metabolic stability in human liver microsomes (HLM) and moderate to good passive permeability in RRCK cells.

[References]

References 1. Dvorak CA, et al. ACS Med Chem Lett. 2015 Jul 20;6(9):1015-8. View Related Products by Target 5-HT Receptor

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₇H₂₁N₃

[ Molecular Weight ]:
267.376

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.