(R)-Nedisertib

Modify Date: 2024-01-09 18:43:33

Use of (R)-Nedisertib

(R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC50 in the range of 7-30 nM for DNA-PK[1].

Name	(R)-Nedisertib

Description	(R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC50 in the range of 7-30 nM for DNA-PK[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK
Target	DNA-PK:7-30 nM (IC50)
In Vitro	Rac-Nedisertib (Compound 135) less actively inhibits DNA-PK, with an IC50 in the range of 7-30 nM[1].
References	[1]. Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1.

Molecular Formula	C₂₄H₂₁ClFN₅O₃
Molecular Weight	481.91