(R)-Nedisertib

Names

[ CAS No. ]:
1637542-32-5

[ Name ]:
(R)-Nedisertib

Biological Activity

[Description]:

(R)-Nedisertib ((R)-M3814) is a less active R-enantiomer of Nedisertib, with an IC50 in the range of 7-30 nM for DNA-PK[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Cell Cycle/DNA Damage >> DNA-PK
Signaling Pathways >> PI3K/Akt/mTOR >> DNA-PK

[Target]

DNA-PK:7-30 nM (IC50)


[In Vitro]

Rac-Nedisertib (Compound 135) less actively inhibits DNA-PK, with an IC50 in the range of 7-30 nM[1].

[References]

[1]. Thomas Fuchss, et al. Arylchinazoline. WO2014183850A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C24H21ClFN5O3

[ Molecular Weight ]:
481.91

Related Compounds